Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection

DA Oyong; JR Loughland; A Sheelanair; D Andrew; FDL Rivera; KA Piera; T William; MJ Grigg; BE Barber; A Haque; CR Engwerda; JS McCarthy; NM Anstey; MJ Boyle

Journal article

Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection

DA Oyong, JR Loughland, A Sheelanair, D Andrew, FDL Rivera, KA Piera, T William, MJ Grigg, BE Barber, A Haque, CR Engwerda, JS McCarthy, NM Anstey, MJ Boyle

Malaria Journal | BMC | Published : 2019

DOI: 10.1186/s12936-019-2962-0

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Abstract

Background: Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs) from the circulation. Complement activation and reduced expression of complement regulatory proteins (CRPs) on RBCs are an important pathogenic mechanism in severe malarial anaemia in both Plasmodium falciparum and Plasmodium vivax infection. However, little is known about loss of CRPs on RBCs during mild malarial anaemia and in low-density infection. Methods: The expression of CRP CR1, CD55, CD59, and the phagocytic regulator CD47, on uninfected normocytes and reticulocytes were assessed in individuals from two study populations: (1) P. falciparum and P. vivax-..

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Ashraful Haque Author

James McCarthy Author

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (NHMRC, Program Grant 1132975 to N. Anstey, J. McCarthy, C Engwerda; Program Grants 1037304 and 1092789; Project Grant 1045156; and Senior Principal Research Fellowship 1042072 to N. Anstey, Practitioner Fellowship 1135955 to J. McCarthy, Senior Research Fellowship 1154265 to C. Engwerda, Project Grant 1125656 and Career Development Award 141632 to M.J. Boyle, Early Career Fellowship 1088738 to B Barber; post graduate scholarship 1074795 and Early Career Fellowship 1138860 to MJG); Charles Darwin University Ph.D. Scholarship to D. Oyong; and Menzies School of Health Research Ph.D. Top-Up Award to D. Oyong. The Burnet Institute is supported by the NHMRC for Independent Research Institutes Infrastructure Support Scheme and the Victoria State Government Operational Infrastructure Support. Funders had no role in the design of the study, nor collection, analysis and interpretation of data, nor writing the manuscript.